| Identification | Back Directory | [Name]
A 61603 HYDROBROMIDE | [CAS]
107756-30-9 | [Synonyms]
A 61603
A 61603 HYDROBROMIDE
N-[5-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2-HYDROXY-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]METHANESULFONAMIDE HYDROBROMIDE
N-(5-(4,5-Dihydro-(1H)-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamidehydrobromide | [Molecular Formula]
C14H20BrN3O3S | [MDL Number]
MFCD02262217 | [MOL File]
107756-30-9.mol | [Molecular Weight]
390.3 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at +4°C | [solubility ]
Soluble in H2O | [form ]
crystalline solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 50 mM in water |
| Hazard Information | Back Directory | [Uses]
A 61603 is a selective α1A-adrenergic receptor agonist. | [Biological Activity]
Potent α -adrenoceptor agonist that is at least 35-fold more potent at α 1A than at α 1B or α 1D sites. Induces dose response increases in spontaneous Ca 2+ transients in rat ventricular myocytes in vitro (EC 50 = 6.9 nmol/L). Also available as part of the α 1 -Adrenoceptor Tocriset™ . | [IC 50]
α1A-adrenergic receptor | [storage]
Store at -20°C | [References]
[1]. knepper sm, buckner sa, brune me, et al. a-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1a receptor subtype. j pharmacol exp ther, 1995, 274(1): 97-103.
[2]. meyer md, altenbach rj, hancock aa, et al. synthesis and in vitro characterization of n-[5-(4,5-dihydro-1h-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1a receptor agonist. j med chem, 1996, 39(20): 4116-4119.
[3]. luo dl, gao j, fan ll, et al. receptor subtype involved in alpha 1-adrenergic receptor-mediated ca2+ signaling in cardiomyocytes. acta pharmacol sin, 2007, 28(7): 968-974.
[4]. martínez-salas sg1, campos-peralta jm, pares-hipolito j, et al. alpha1a-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. auton autacoid pharmacol, 2007, 27(3): 137-142. |
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