| Identification | Back Directory | [Name]
CAY10589 | [CAS]
1077626-52-8 | [Synonyms]
CAY10589
CAY10589 Exclusive
FQMPYBCEABTPIK-UHFFFAOYSA-N
Octanoic acid, 2-[[4-[([1,1'-biphenyl]-4-ylmethyl)amino]-6-chloro-2-pyrimidinyl]thio]- | [Molecular Formula]
C25H28ClN3O2S | [MOL File]
1077626-52-8.mol | [Molecular Weight]
470.03 |
| Chemical Properties | Back Directory | [Boiling point ]
648.1±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
3.04±0.21(Predicted) |
| Hazard Information | Back Directory | [Description]
Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM. | [Uses]
CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs[1][2]. | [Definition]
ChEBI: CAY10589 is a member of biphenyls. | [storage]
Store at -20°C | [References]
[1] Wiegard A, et al. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. Eur J Med Chem. 2012 Feb;48:153-63. DOI:10.1016/j.ejmech.2011.12.009
[2] Li L, et al. Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy. Cell Oncol (Dordr). 2023 Sep 30. DOI:10.1007/s13402-023-00881-y |
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