| Identification | Back Directory | [Name]
Gadermandiol | [CAS]
107900-76-5 | [Synonyms]
Gadermandiol
GanoderManondiol
Lanosta-7,9(11)-dien-3-one,24,25-dihydroxy-, (24S)-
(5R,10S,13R,14R,17R)-17-[(2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one | [Molecular Formula]
C30H48O3 | [MDL Number]
MFCD20260670 | [MOL File]
107900-76-5.mol | [Molecular Weight]
456.7 |
| Chemical Properties | Back Directory | [Boiling point ]
580.4±50.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
14.67±0.29(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum[1].Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity[2]. Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM[3]. Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM[4]. | [Definition]
ChEBI: Ganodermanondiol is a triterpenoid. | [References]
[1] Kim JW, et al. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int J Mol Sci. 2016 Oct 27;17(11). DOI:10.3390/ijms17111798
[2] Li B, et al. Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. Food Chem Toxicol. 2013 Mar;53:317-24. DOI:10.1016/j.fct.2012.12.016
[3] Min BS, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. DOI:10.1248/cpb.46.1607
[4] Min BS, et al. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001 Dec;67(9):811-4. DOI:10.1055/s-2001-18854 |
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