| Identification | Back Directory | [Name]
Tazofelone, LY-213829 | [CAS]
107902-67-0 | [Synonyms]
LY-213829
Tazofelone, LY-213829
5-(3,5-Di-tert-butyl-4-hydroxybenzyl)thiazolidin-4-one
4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]- | [Molecular Formula]
C18H27NO2S | [MDL Number]
MFCD00868113 | [MOL File]
107902-67-0.mol | [Molecular Weight]
321.48 |
| Hazard Information | Back Directory | [Biological Activity]
Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. Tazofelone transform into sulfoxide and quinol metabolites is primarily mediated by CYP3A. Tazofelone can be used for the research of inflammatory bowel disease[1][2]. | [References]
[1]. Leopold Franz Goetze,et al. Cox- ii inhibitors for improving reproductive success in a female animal. Patent: WO2007129169 A2. [2]. Surapaneni SS, et al. In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone. Drug Metab Dispos. 1997 Dec;25(12):1383-8. |
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