| Identification | Back Directory | [Name]
DENDROTOXIN I | [CAS]
107950-33-4 | [Synonyms]
DPI
DTX-I
DENDROTOXIN I
Dendrotoxin-I from Dendroaspis polylepis polylepis venom
PYR-PRO-LEU-ARG-LYS-LEU-CYS-ILE-LEU-HIS-ARG-ASP-PRO-GLY-ARG-CYS-TYR-GLN-LYS -ILE-PRO-ALA-PHE-TYR-TYR-ASN-GLN-LYS-LYS-LYS-GLN-CYS-GLU-GLY-PHE-THR-TRP-SER-GLY-CYS-GLY-GLY-ASN-SER-ASN-ARG-PHE-LYS-THR-ILE-GLU-GLU-CYS-ARG-ARG-THR -CYS-ILE-ARG-LYS | [MDL Number]
MFCD00166526 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
lyophilized powder
| [Sequence]
Gln-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bridge:Cys7-Cys57;Cys16-Cys40;Cys32-Cys53) |
| Hazard Information | Back Directory | [Uses]
Dendrotoxin-I (DTX-I) is a potent K+ channels blocker with IC50s of 0.13-50 nM for voltage-gated potassium channel subunits KV1.1, KV1.2 and KV1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research[1][2][3]. | [in vivo]
Dendrotoxin-I (5 mg/kg; IV) displays a significant tumor growth inhibition effect combined with hyperthermia[3]. | Animal Model: | Nude mice with MCF-7 cells[3] | | Dosage: | 5 mg/kg | | Administration: | IV | | Result: | Displayed a significanttumor growth inhibition effect combined with hyperthermia.
Could not keep on inhibiting the growth of tumor at the later period of treatment.
|
| [IC 50]
Kv1.1: 0.13-50 nM (IC50); Kv1.2: 0.13-50 nM (IC50); Kv1.6: 0.13-50 nM (IC50) | [References]
[1] Qiwen Liao, et al. Novel Kunitz-like Peptides Discovered in the Zoanthid Palythoa caribaeorum through Transcriptome Sequencing. J Proteome Res. 2018 Feb 2;17(2):891-902. DOI:10.1021/acs.jproteome.7b00686
[2] Tess Wright, et al. Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3. Sci Rep. 2016 Jun 23;6:28584. DOI:10.1038/srep28584
[3] Hui Zhang, et al. Preparation, characterization, and pharmacodynamics of thermosensitive liposomes containing docetaxel. J Pharm Sci. 2014 Jul;103(7):2177-2183. DOI:10.1002/jps.24019 |
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