| Identification | Back Directory | [Name]
1H-Indol-5-ol,3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-, hydrochloride (1:1) | [CAS]
108050-82-4 | [Synonyms]
1H-Indol-5-ol,3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-, hydrochloride (1:1) | [Molecular Formula]
C23H27ClN2O | [MOL File]
108050-82-4.mol | [Molecular Weight]
382.926 |
| Chemical Properties | Back Directory | [Melting point ]
274° | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 50 mM in DMSO with gentle warming | [form ]
Powder | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Roxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist. | [in vivo]
Roxindole hydrochloride inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1].
Roxindole hydrochloride (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3]. | [IC 50]
D2 Receptor | [storage]
Desiccate at -20°C |
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BOC Sciences
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https://www.bocsci.com |
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