| Identification | Back Directory | [Name]
Ganoderic acid D | [CAS]
108340-60-9 | [Synonyms]
(7beta)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid
Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)- | [Molecular Formula]
C30H42O7 | [MDL Number]
MFCD32197327 | [MOL File]
108340-60-9.mol | [Molecular Weight]
514.65 |
| Chemical Properties | Back Directory | [Boiling point ]
688.3±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light | [solubility ]
Soluble in methanol; | [form ]
powder | [pka]
4.77±0.23(Predicted) | [color ]
White | [Water Solubility ]
insoluble in water |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family. | [Uses]
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2]. | [General Description]
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [Biological Activity]
Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum th at exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptakelactateand pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition. | [IC 50]
SIRT3 | [References]
[1] Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77. DOI:10.1016/j.ejphar.2018.01.026
[2] Yue QX, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61. DOI:10.1074/mcp.M700259-MCP200 |
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