| Identification | Back Directory | [Name]
8-Deoxyenterocin | [CAS]
108605-51-2 | [Synonyms]
Deoxyenterocin
8-Deoxyenterocin
3,6-Methanocyclopenta[c]pyran-1(3H)-one, 7-benzoylhexahydro-4a,6,7a-trihydroxy-5-(4-methoxy-2-oxo-2H-pyran-6-yl)-, (3S,4aR,5S,6S,7S,7aS)- | [Molecular Formula]
C22H20O9 | [MDL Number]
MFCD00874304 | [MOL File]
108605-51-2.mol | [Molecular Weight]
428.39 |
| Hazard Information | Back Directory | [Description]
Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. It inhibits the growth of S. lutea, S. aureus, K. pneumoniae, and V. percolans in vitro when used at a concentration of 500 μg/ml. Deoxyenterocin (50 μg/ml) inhibits the cytopathic effect of influenza A H1N1 virus by 60.6% in vitro. It also prevents hydrogen peroxide-induced decreases in glutathione (GSH) levels and in the mitochondrial membrane potential in mouse primary cortical neuronal cultures when used at a concentration of 1 μM. | [Uses]
Deoxyenterocin is a co-metabolite that exhibits activity against Gram positive and negative bacteria. | [Uses]
Deoxyenterocin is a minor co-metabolite of enterocin produced by several species of Streptomyces. Interestingly, deoxyenterocin was first isolated from an ascidian. Like enterocin, deoxyenterocin exhibits activity against both Gram positive and Gram negative bacteria but lack of availability has restricted a more extensive evaluation. | [storage]
Store at -20°C | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] HAISHAN LIU . Phenolic polyketides from the marine alga-derived Streptomyces sp. OUCMDZ-3434[J]. Tetrahedron, 2017, 73 36: Pages 5451-5455. DOI: 10.1016/j.tet.2017.07.052
[3] MARTA LEIRóS. Mitigation of ROS Insults by Streptomyces Secondary Metabolites in Primary Cortical Neurons[J]. ACS Chemical Neuroscience, 2013, 5 1: 71-80. DOI: 10.1021/cn4001878 |
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