| Identification | Back Directory | [Name]
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE | [CAS]
108825-65-6 | [Synonyms]
Lin28 1632
Lin28-IN-1632
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]- | [Molecular Formula]
C15H15N5O | [MDL Number]
MFCD01567008 | [MOL File]
108825-65-6.mol | [Molecular Weight]
281.31 |
| Chemical Properties | Back Directory | [Melting point ]
200 °C | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
A crystalline solid | [pka]
0.57±0.30(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3 | [InChIKey]
WPAQLESUVYGUJZ-UHFFFAOYSA-N | [SMILES]
[n]21nc(ccc2nnc1C)c3cc(ccc3)N(C)C(=O)C |
| Hazard Information | Back Directory | [Uses]
Lin28 1632 is a small molecule inhibitor of Lin28. | [Biological Activity]
Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNAbut not RNU44 snoRNA (60 μM for 48h)inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs20 μM for 48h)as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM). | [storage]
Store at -20°C |
|
| Company Name: |
DebyeTec.com Inc.
|
| Tel: |
18086626237 18086626237 |
| Website: |
www.chemicalbook.com/showsupplierproductslist16955/0.htm |
|