ChemicalBook--->CAS DataBase List--->1088715-84-7

1088715-84-7

Request For Quotation
1088715-84-7 Structure

1088715-84-7 Structure
IdentificationBack Directory
[Name]

Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
[CAS]

1088715-84-7
[Synonyms]

CS-2675
LY2510924
LY2510924; LY-2510924; LY 2510924
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2
Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2A
L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam
[Molecular Formula]

C62H88N14O10
[MDL Number]

MFCD31728513
[MOL File]

1088715-84-7.mol
[Molecular Weight]

1189.45
Chemical PropertiesBack Directory
[density ]

1.33±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 125 mg/mL (105.09 mM)
[form ]

Solid
[pka]

9.89±0.15(Predicted)
[color ]

White to off-white
[InChIKey]

IJHWVENTEFSNBC-QBSDWBABNA-N
Hazard InformationBack Directory
[Uses]

LY2510924 is a CXC chemokine receptor 4 inhibitor and a potential antineoplastic agent.
[in vivo]

LY2510924 specifically blocks SDF-1 binding to CXCR4 with IC50 value of 0.079 nM, and inhibits SDF-1–induced GTP binding with Kb value of 0.38 nM. In human lymphoma U937 cells expressing endogenous CXCR4, LY2510924 inhibits SDF-1–induced cell migration with IC50 value of 0.26 nM and inhibits SDF-1/CXCR4-mediated intracellular signaling. LY2510924 exhibits a concentration-dependent inhibition of SDF-1–stimulated phospho-ERK and phospho-Akt in tumor cells. Biochemical and cellular analyses reveals that LY2510924 has no apparent agonist activity[1]. LY2510924 chiefly inhibits the proliferation of AML cells with little induction of cell death and reduces protection against chemotherapy by stromal cells[2].

[IC 50]

125I-SDF-1α-CXCR4: 79.7 pM (IC50); 125I-SDF-1α-CXCR4: 49.5 pM (Ki)
[storage]

Store at -20°C
1088715-84-7 suppliers list
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-164-7117 18317119277
Website: www.bidepharm.com
Company Name: Wuxi Zhongkun Biochemical Technology Co., Ltd.  
Telephone: 0510-85629785 18013409632;
Website: www.reading-chemicals.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Telephone: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: Guangzhou Zhiya Chemdrugs Co.,Ltd  
Telephone: 18122150900
Website: http://www.tiewill.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 18916372613
Website: www.shyuanye.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Telephone: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Beijing Solarbio Science & Tecnology Co., Ltd.  
Telephone: 17801761073 18101056239
Website: http://www.solarbio.com
Company Name: Nanjing Leon Biological Technology Co., Ltd.  
Telephone: 025-84523390 -127; 17705183659
Website: http://www.njleonbiotech.com
Company Name: Nanjing Peptide Biotech Ltd.  
Telephone: 025-58361106-805 15951641583
Website: http://www.njpeptide.com
Company Name: Twochem Co.Ltd.  
Telephone: 021-58111628 15800915896
Website: cn.twochem.com
Company Name: Hangzhou Peptidego Biotech Co.,Ltd.  
Telephone: 0571-87213919 15967184799
Website: peptidego.com
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Telephone: 15911056312
Website: www.bio-fount.com
Company Name: Tianjin Kaifu Pharmaceutical Technology Co., Ltd.  
Telephone: 18081075745
Website: www.chemicalbook.com/ShowSupplierProductsList31177/0_EN.htm
Company Name: Nanjing Meihao Pharmaceutical Technology Co., Ltd.  
Telephone: meitaochem@126.com
Website: www.chemicalbook.com/ShowSupplierProductsList31244/0_EN.htm
Company Name: Zhejiang J&C Biological Technology Co.,Limited  
Telephone: +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD  
Telephone: 86-571-88216897,88216896 13588875226
Website: www.hzclap.com/en
Company Name: Lotusland Life Sciences  
Telephone: +8615821988213
Website: https://www.chemicalbook.com/manufacturer/shanghai-longyu-biotechnology-164/
Tags:1088715-84-7 Related Product Information
1433497-19-8 1386874-06-1 946518-61-2 1951483-29-6 1898283-02-7 1627696-51-8 1346133-11-6 177744-96-6 396129-53-6 946518-60-1 1229236-86-5 1082949-67-4 161172-51-6 862507-23-1 1103500-20-4 1231220-79-3 1307245-86-8 154447-36-6