| Identification | Back Directory | [Name]
Taccalonolide B | [CAS]
108885-69-4 | [Synonyms]
Taccalonolide B
ETaccalonolide B
16,24-Cycloergost-22-en-26-oic acid, 1,11,12-tris(acetyloxy)-2,3-epoxy-7,15,23,25-tetrahydroxy-6-oxo-, γ-lactone, (1α,2α,3α,5α,7β,11α,12α,15α,16β,24β,25S)-
(1alpha,2alpha,3alpha,5alpha,7beta,11alpha,12alpha,15alpha,16beta,24beta,25S)-1,11,12-Tris(acetyloxy)-2,3-epoxy-7,15,23,25-tetrahydroxy-6-oxo-16,24-cycloergost-22-en-26-oic acid gamma-lactone | [Molecular Formula]
C34H44O13 | [MDL Number]
MFCD30725005 | [MOL File]
108885-69-4.mol | [Molecular Weight]
660.71 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [InChIKey]
FFQOXBQSZPYHSA-MPOUNFKCSA-N |
| Hazard Information | Back Directory | [Uses]
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2]. | [storage]
Store at -20°C | [References]
[1] LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675.
[2] Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8. DOI:10.1158/0008-5472.CAN-08-2037 |
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