| Identification | Back Directory | [Name]
trans-trismethoxy Resveratrol-d4 | [CAS]
1089051-64-8 | [Synonyms]
trans-trismethoxy Resveratrol-d4
1,2,4,5-tetradeuterio-3-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-6-methoxybenzene | [Molecular Formula]
C17H14D4O3 | [MDL Number]
MFCD11976909 | [MOL File]
1089051-64-8.mol | [Molecular Weight]
274.348 |
| Hazard Information | Back Directory | [Description]
trans-trismethoxy Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-trismethoxy resveratrol by GC- or LC-MS. trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively). trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM. | [Uses]
trans-Trismethoxy Resveratrol-d4 is the deuterium labeled trans-Trismethoxy Resveratrol[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
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