| Identification | Back Directory | [Name]
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln | [CAS]
109053-09-0 | [Synonyms]
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln
L-Glutamine, glycyl-L-prolyl-L-leucylglycyl-L-isoleucyl-L-alanylglycyl- | [Molecular Formula]
C31H53N9O10 | [MDL Number]
MFCD30602097 | [MOL File]
109053-09-0.mol | [Molecular Weight]
711.81 |
| Chemical Properties | Back Directory | [Boiling point ]
1220.2±65.0 °C(Predicted) | [density ]
1.267±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.25±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln |
| Hazard Information | Back Directory | [Uses]
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT)[1][2][3]. | [Biological Activity]
Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln（GPLGIAGQ）, an MMP2 cleavable polypeptide, has been used as a stimulus-sensitive linker in both liposomes and micellar nanocarriers for MMP2-triggered tumor targeting studies. GPLGIAGQ can be used to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). | [in vitro]
GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization. | [References]
[1] Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8(2):1447-57. DOI:10.1021/acsami.5b10772
[2] Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35(13):4213-22. DOI:10.1016/j.biomaterials.2014.01.060
[3] Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6(3):604-613. DOI:10.1039/c7bm01182b |
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