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1092851-70-1

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1092851-70-1 Structure

1092851-70-1 Structure
IdentificationBack Directory
[Name]

HO-1-IN-1 hydrochloride
[CAS]

1092851-70-1
[Synonyms]

HO-1-IN-1 hydrochloride
HO-1 inhibitor 1 hydrochloride
[Molecular Formula]

C??H??BrClN?
[MDL Number]

MFCD32067876
[MOL File]

1092851-70-1.mol
[Molecular Weight]

315.64
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 125 mg/mL (396.02 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM[1].
[References]

[1] Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. DOI:10.1016/j.bioorg.2018.08.023
[2] Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. DOI:10.1016/j.freeradbiomed.2023.03.024
[3] Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. DOI:10.1007/s10120-020-01111-2
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