| Identification | Back Directory | [Name]
HO-1-IN-1 | [CAS]
1093058-52-6 | [Synonyms]
HO-1-IN-1
HO-1 inhibitor 1
1H-Imidazole, 1-[4-(4-bromophenyl)butyl]- | [Molecular Formula]
C13H15BrN2 | [MDL Number]
MFCD32062695 | [MOL File]
1093058-52-6.mol | [Molecular Weight]
279.18 |
| Chemical Properties | Back Directory | [Boiling point ]
435.0±28.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (447.74 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
7.06±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1]. | [storage]
Store at -20°C | [References]
[1] Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339. DOI:10.1016/j.bioorg.2018.08.023
[2] Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. DOI:10.1016/j.freeradbiomed.2023.03.024
[3] Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24(1):117-132. DOI:10.1007/s10120-020-01111-2 |
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| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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