| Identification | Back Directory | [Name]
B-Raf inhibitor 1 | [CAS]
1093100-40-3 | [Synonyms]
CS-927
or Base
Raf inhibitor 1
BRAF inhibitor 13
B-Raf inhibitor 1
B-Raf inhibitor 1 Base
B-Raf inhibitor 1, >=98%
N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine
1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-
1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine | [Molecular Formula]
C26H19ClN8 | [MDL Number]
MFCD22571725 | [MOL File]
1093100-40-3.mol | [Molecular Weight]
478.94 |
| Chemical Properties | Back Directory | [Boiling point ]
735.4±60.0 °C(Predicted) | [density ]
1.461±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥ 47.9mg/mL in DMSO | [form ]
Solid | [pka]
8.41±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. | [Biological Activity]
B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively. | [in vitro]
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. | [target]
| B-Raf < span> 1 nM (Ki) | B-Raf V600E 1 nM (Ki) | c-Raf 0.3 nM (Ki ) | | [IC 50]
B-Raf: 1 nM (Ki); B-RafV600E: 1 nM (Ki); c-Raf: 0.3 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41. DOI:10.1021/jm300613w |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
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