| Identification | Back Directory | [Name]
AP-761 | [CAS]
1093108-50-9 | [Synonyms]
AP-761
BI671800
AP-761 / BI671800
BI 671800
(BI671800)
BI671800;AP-761;AP761;AP 761
5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]- | [Molecular Formula]
C25H26F3N5O3 | [MOL File]
1093108-50-9.mol | [Molecular Weight]
501.5 |
| Chemical Properties | Back Directory | [Boiling point ]
611.4±55.0 °C(Predicted) | [density ]
1.351±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: soluble | [form ]
A crystalline solid | [pka]
3.20±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BI-671800 is a selective and potent CRTH2 antagonist. | [in vivo]
BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1].
BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3]. | Animal Model: | 6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally)[1].
| | Dosage: | 10-0.1 mg/kg | | Administration: | Oral gavage for 4 weeks | | Result: | Shows significant inhibition of AHR in mice. |
| [IC 50]
hCRTH2: 4.5 nM (IC50); mCRTH2: 3.7 μM (IC50) | [storage]
4°C, protect from light |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|