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1093108-50-9

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1093108-50-9 Structure

1093108-50-9 Structure
IdentificationBack Directory
[Name]

AP-761
[CAS]

1093108-50-9
[Synonyms]

AP-761
BI671800
AP-761 / BI671800
BI 671800 (BI671800)
BI671800;AP-761;AP761;AP 761
5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-
[Molecular Formula]

C25H26F3N5O3
[MOL File]

1093108-50-9.mol
[Molecular Weight]

501.5
Chemical PropertiesBack Directory
[Boiling point ]

611.4±55.0 °C(Predicted)
[density ]

1.351±0.06 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO: soluble
[form ]

A crystalline solid
[pka]

3.20±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

BI-671800 is a selective and potent CRTH2 antagonist.
[in vivo]

BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1].
BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3].

Animal Model:6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally)[1].
Dosage:10-0.1 mg/kg
Administration:Oral gavage for 4 weeks
Result:Shows significant inhibition of AHR in mice.
[IC 50]

hCRTH2: 4.5 nM (IC50); mCRTH2: 3.7 μM (IC50)
[storage]

4°C, protect from light
Spectrum DetailBack Directory
[Spectrum Detail]

AP-761(1093108-50-9)1HNMR
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