| Identification | Back Directory | [Name]
(D-ARG0,HYP3,D-PHE7)-BRADYKININ | [CAS]
109333-26-8 | [Synonyms]
npc567
D-ARG-[HYP3,D-PHE7]-BRADYKININ
(D-Arg0,Hyp3,D-Phe7)bradikinin
(D-ARG0,HYP3,D-PHE7)-BRADYKININ
D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG
H-D-ARG-ARG-PRO-HYP-GLY-PHE-SER-D-PHE-PHE-ARG-OH
D-Arg-Arg-Pro-t4Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH
D-ARG-ARG-PRO-HYDROXY-PRO-GLY-PHE-SER-D-PHE-PHE-ARG
D-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-D-Arg-OH
D-Arg-L-Arg-L-Pro-L-t4Hyp-Gly-L-Phe-L-Ser-D-Phe-L-Phe-L-Arg-OH
D-Arg-L-Arg-L-Pro-4-Hydroxy-L-Pro-Gly-L-Phe-L-Ser-D-Phe-L-Phe-L-Arg-OH
Bradykinin, N2-D-arginyl-3-[(4R)-4-hydroxy-L-proline]-7-D-phenylalanine-
(D-Arg0, Hyp 3,D-Phe7)-Bradykinin trifluoroacetate salt H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Phe-Phe-Arg-OH trifluoroacetate salt | [Molecular Formula]
C60H87N19O13 | [MDL Number]
MFCD00076269 | [MOL File]
109333-26-8.mol | [Molecular Weight]
1282.45 |
| Hazard Information | Back Directory | [Uses]
NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2]. | [Definition]
ChEBI: A ten-membered oligopeptide comprising D-arginyl, L-arginyl, L-prolyl, (4R)-4-hydroxy-L-prolyl, glycyl, L-phenylalanyl, L-seryl,
-phenylalanyl, L-phenylalanyl and L-arginine residues joined in sequence. | [References]
[1] Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72. DOI:10.1021/jm00087a010
[2] Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9. DOI:10.1007/PL00000270 |
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