| Identification | Back Directory | [Name]
Englerin A | [CAS]
1094250-15-3 | [Synonyms]
Englerin A
(-)-ENGLERIN A
(?)-Englerin A
Englerin A high purity
(1S,2R,5R,6R,7S,8R,10R)-10-(Glycoloyloxy)-8-isopropyl-1,5-dimethyl-11-oxatricyclo[6.2.1.02,6]undec-7-yl(2E)-3-phenylacrylate
2-Propenoic acid, 3-phenyl-, (1R,3aR,4S,5R,7R,8S,8aR)-decahydro-5-[(2-hydroxyacetyl)oxy]-1,4-dimethyl-7-(1-methylethyl)-4,7-epoxyazulen-8-yl ester, (2E)- | [Molecular Formula]
C26H34O6 | [MDL Number]
MFCD32068367 | [MOL File]
1094250-15-3.mol | [Molecular Weight]
442.54 |
| Chemical Properties | Back Directory | [Boiling point ]
550.3±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.88±0.10(Predicted) | [color ]
White to light yellow | [Major Application]
food and beverages | [InChIKey]
GACOFEKSDCOVMV-ACCUITESSA-N | [SMILES]
O1C2(C3C(C(C1(CC2OC(=O)CO)C(C)C)OC(=O)\C=C\c4ccccc4)C(CC3)C)C |
| Hazard Information | Back Directory | [Uses]
Englerin A is a selective inhibitor of renal cancer cell growth. | [Definition]
ChEBI: Englerin A is a guaiane sesquiterpenoid that is isolated from the bark of Phyllanthus engleri, a plant native to Tanzania and Zimbabwe. It acts as a potent and specific inhibitor of renal cancer cell growth. It has a role as a metabolite and an antineoplastic agent. It is a guaiane sesquiterpenoid, a cinnamate ester and a glycolate ester. | [in vivo]
Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice[4]. | [IC 50]
hTRPC4: 11.2 nM (EC50); hTRPC5: 7.6 nM (EC50) |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|