| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [pka]
3.70±0.10(Predicted) | [Sequence]
Ac-{d-Phe}-{d-Phe}-{d-Trp}-Ser-Tyr-{d-Har}-Leu-Arg-Pro-{d-Ala} |
| Hazard Information | Back Directory | [Description]
RS 18286 is a LHRH antagonist. | [Uses]
RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids[1]. | [References]
[1] Lincoln GA, et al. Compensatory response of the luteinizing-hormone (LH)-releasing hormone (LHRH)/LH pulse generator after administration of a potent LHRH antagonist in the ram. Endocrinology. 1987 Jun;120(6):2245-50. DOI:10.1210/endo-120-6-2245 |
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