| Identification | Back Directory | [Name]
1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea | [CAS]
1095173-64-0 | [Synonyms]
EOS-62277
Glasdegib hydrochloride
1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea hydrochloride
1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea hydrochloride
Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-, hydrochloride (1:1) | [Molecular Formula]
C21H23ClN6O | [MOL File]
1095173-64-0.mol | [Molecular Weight]
410.91 |
| Hazard Information | Back Directory | [Uses]
Glasdegib hydrochloride is a potent and orally bioavailable smoothened inhibitor. Glasdegib hydrochloride (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1]. | [References]
[1] Sadarangani A, et al. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21;13:98. DOI:10.1186/s12967-015-0453-9 |
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