| Identification | Back Directory | [Name]
N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide | [CAS]
109844-92-0 | [Synonyms]
N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
2-Furancarboxamide, N-(4-chlorophenyl)-5-nitro-
5-nitro-furan-2-carboxylic acid-(4-chloro-anilide) | [Molecular Formula]
C11H7ClN2O4 | [MOL File]
109844-92-0.mol | [Molecular Weight]
266.64 |
| Chemical Properties | Back Directory | [Melting point ]
181 °C | [Boiling point ]
328.2±37.0 °C(Predicted) | [density ]
1.524±0.06 g/cm3(Predicted) | [solubility ]
DMF: slightly; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
11.00±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LCS3 is a reversible and uncompetitive glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) inhibitor (IC50=3.3 μM and 3.8 μM, respectively). LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research[1]. | [References]
[1] Fraser D Johnson, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022 Feb 8;38(6):110343. DOI:10.1016/j.celrep.2022.110343 |
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