| Identification | Back Directory | [Name]
ALPHA-ACTININ | [CAS]
11003-00-2 | [Synonyms]
α-Actinin
ALPHA-ACTININ
A-actinin from chicken gizzard
α-actinin from chicken gizzard
α-Actinin from chicken gizzard | [MDL Number]
MFCD00130473 |
| Hazard Information | Back Directory | [Uses]
α-Actinin from chicken gizzard has been used:
- as an antigen to coat plates for the capture of anti-actinin antibody using enzyme-linked immunosorbent assay (ELISA) from tumor cell line clones
- in in vitro motility experiments to test its effect on actin filament movement
- to coat cantilevers for strengthening fluorescently labeled actin filaments in force measurement studies
| [General Description]
α-Actinin exists as a rod-shaped antiparallel dimer with two elongated subunits. The domain region contains an N-terminal actin-binding domain with tandem calponin homology domains, a central tandem 3-helix motifs, and EF-hand motifs at C-terminus. It belongs to the spectrin superfamily and is localized in actin structures. | [Biochem/physiol Actions]
α-Actinin binds actin and has the ability to crosslink actin cytoskeleton. It also plays a key role in the structural maintenance of the Z-disk of striated muscle. |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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