| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A solid | [color ]
Brown to orange |
| Hazard Information | Back Directory | [Description]
MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling. | [Uses]
MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2-to H2O2[1]. | [References]
[1] Trnka J, et al. A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med. 2008;44(7):1406-1419. DOI:10.1016/j.freeradbiomed.2007.12.036 |
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| Company Name: |
Abcam Limited
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| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
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