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[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1]. | [in vivo]
[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1]. | Animal Model: | New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1] | | Dosage: | 3.6-4.0 μg/kg | | Administration: | i.v.; single dosage | | Result: | Suppressed hyperglycemic response of glucagon. |
| Animal Model: | Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1] | | Dosage: | 1 mg/kg | | Administration: | Intravenously administration through the tail vein; single dosage | | Result: | Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min. |
| [References]
[1] Unson CG, et al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov-Dec;10(6):1171-7. DOI:10.1016/0196-9781(89)90010-7 |
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