| Identification | Back Directory | [Name]
AZD3147 | [CAS]
1101810-02-9 | [Synonyms]
AZD3147
1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-(2-hydroxyethyl)thiourea
N-[4-[4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)thiourea
Thiourea, N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)- | [Molecular Formula]
C24H31N5O4S2 | [MDL Number]
MFCD28411426 | [MOL File]
1101810-02-9.mol | [Molecular Weight]
517.66 |
| Chemical Properties | Back Directory | [Boiling point ]
696.7±65.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: <100 mM; Ethanol: >1 mg/ml; Hydrochloric Acid: <100 mM | [form ]
A solid | [pka]
11.71±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
AZD3147 is a selective dual inhibitor of mTORC1 and mTORC2 with physiochemical and pharmacokinectic properties suitable for clinical applications. | [in vivo]
The pharmacokinetic parameters of AZD3147[1].
| Parameter | Mouse | Dog | | CL (mL/min/kg) | 78 | 16 | | Vss (L/kg) | 2.3 | 2.2 | | t1/2(h) | 0.9 | 1.9 | | F% | 61 | 73 | |
| [IC 50]
mTORC1; mTORC2 |
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