| Identification | Back Directory | [Name]
oligomycin E | [CAS]
110231-34-0 | [Synonyms]
oligomycin E
26-Hydroxy-28-oxooligomycin A
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone,22-ethyl-5',6'-dihydro-7,11,14,15,28-pentahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1S,2'R,5'R,6R,6'R,7S,7E,8R,10S,11S,12R,14S,15R,16S,21E,22S,23E,25R,28S,29S)-
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15,28-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28R,29R)- | [Molecular Formula]
C45H72O13 | [MDL Number]
MFCD30145908 | [MOL File]
110231-34-0.mol | [Molecular Weight]
821.05 |
| Chemical Properties | Back Directory | [Boiling point ]
940.6±65.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A lyophilisate | [pka]
12.52±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Oligomycin E is a minor metabolite of the oligomycin complex produced by several species of Streptomyces. It exhibits relatively weak antifungal activity compared to other oligomycins, yet is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC50 = 14 ng/ml). | [Uses]
Oligomycin E (26-hydroxyoligomycin B) is a minor metabolite from the oligomycin complex produced by several species of Streptomyces. Unlike the other oligomycins, oligomycin E exhibits weak antibacterial activity and is considerably weaker as an antifungal agent. | [Uses]
Oligomycin E is a minor metabolite from the oligomycin complex with weak antibacterial and antifungal activity. | [storage]
Store at -20°C | [References]
[1] K KOBAYASHI. Oligomycin E, a new antitumor antibiotic produced by Streptomyces sp. MCI-2225.[J]. Journal of Antibiotics, 1987, 40 7: 1053-1057. DOI: 10.7164/antibiotics.40.1053 |
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