| Identification | Back Directory | [Name]
SANTALOL | [CAS]
11031-45-1 | [Synonyms]
SANTALOL
FEMA 3006
β-Santalol
D-ALPHA-SANTALOL
A AND B-SANTALOL
CIS-ALPHA-SANTALOL
2-Methyl-5-((1S,2S,4R)
SANTALOL (ALPHA AND BETA )
Santalol, α- and β-isomers
SANTALOL ALPHA- AND BETA- FCC
Santalol, alpha- and beta-isomers
-2-methyl-3-methylenebicyclo[2.2.1]heptan-2-yl)
2-PENTEN-1-OL, 5-(2,3-DIMETHYL TRICYCLO [2.2.1.0(2,6)] HEPT-3-YL)-2-METHYL
2-Methyl-5-((1S,2S,4R)-2-Methyl-3-Methylenebicyclo[2.2.1]heptan-2-yl)pent-2-en-1-ol | [EINECS(EC#)]
234-262-4 | [Molecular Formula]
C15H24O | [MDL Number]
MFCD00046301 | [MOL File]
11031-45-1.mol | [Molecular Weight]
220.35 |
| Chemical Properties | Back Directory | [density ]
0.968 g/mL at 25 °C(lit.) | [FEMA ]
3006 | SANTALOL (ALPHA AND BETA ) | [refractive index ]
n20/D 1.507(lit.) | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless | [Odor]
at 100.00 %. deep sweet sandalwood woody | [Odor Type]
woody | [JECFA Number]
984 | [Boiling point ]
101-103°C/0.1 mmHg(lit.) | [LogP]
4.65 | [Uses]
Santalol is a flavoring agent that is a colorless or pale yellow liquid,
with odor resembling sandalwood. it is soluble in alcohol, fixed oils,
mineral oil, and propylene glycol; and insoluble in water and glyc-
erin. it is obtained from a sandalwood oil source. | [EPA Substance Registry System]
Santalol (11031-45-1) |
| Hazard Information | Back Directory | [Chemical Properties]
Santalol (α- and β-) has a sweet, sandalwood odor. | [Occurrence]
The stereochemistry of santalols has been discussed by Brieger (Burdock, 1995); santalols are found among the constituents of various sandalwood species (Santalum album L., S. spicatum, S. autrocaledonicum); the α- and β-isomers are present in varying ratios, with the α-isomer usually more abundant. | [Synthesis]
The commercial product is generally a mixture of α- and β-santalol obtained by fractional distillation of sandalwood oil; noncommercial syntheses are known. | [in vivo]
α-Santalol (i.p. 12.5 mg/kg, 25 mg/kg, 50 mg/kg) prolongs the sleeping time more than β-Santalol when they were each administered intragastrically in male ddY mice[3].
α-Santalol (i.p. 12.5 mg/kg, 25 mg/kg, 50 mg/kg) reduces rectal temperature in a dose-related manner following i.p. administration and the magnitude of activity is greater than that of β-Santalol in male ddY mice [3].
α-Santalol and β-Santalol (p.o., 50 mg/kg, 100 mg/kg, 200 mg/kg) shows significant antinociceptive activities in male ddY mice[3].
α-Santalol and β-Santalol (i.p., 50 mg/kg) decreases spontaneous activity and simultaneously shows motor incoordination, such as catalepsy, but does not cause ptosis, hypnosis and muscle relaxation in male ddY mice [3].
α-Santalol (i.p., 25 mg/kg, 50 mg/kg) causes a greater reduction in methamphetamine-induced (at 2 mg/kg) motilities than β-Santalol in male ddY mice [3].
α-Santalol and β-Santalol (i.p., 25 mg/kg, 50 mg/kg) significantly decreases apomorphine-induced (2 mg/kg) movements in male ddY mice [3].
α-Santalol (i.p., 50 mg/kg) significantly increases the levels of HVA (homovanillic acid), and 5-HIAA (5-hydroxyindoleacetic acid) in the brain of treated mice[3].
β-Santalol (i.p., 50 mg/kg) increases the levels of DOPAC (3,4-dihydroxyphenylacetic acid), and 5-HT(serotonin creatinine sulfate) besides HVA and 5-HIAA in male ddY mice[3].
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