| Identification | Back Directory | [Name]
9-Anthracenemethanol, α-[4-(acetyloxy)phenyl]-, 9-acetate | [CAS]
1103745-28-3 | [Synonyms]
TM233
TM-233
TM 233
9-Anthracenemethanol, α-[4-(acetyloxy)phenyl]-, 9-acetate | [Molecular Formula]
C25H20O4 | [MOL File]
1103745-28-3.mol | [Molecular Weight]
384.43 |
| Hazard Information | Back Directory | [Description]
TM-233 is an inhibitor of both JAK/STAT and proteasome activities. It acts by inducing cell death in myeloma cells. | [Uses]
TM-233 is an inhibitor of the JAK/STAT and NF-κB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-κB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-κB expression. TM-233 shows potential in overcoming Bortezomib (HY-10227) resistance and can be applied in research related to multiple myeloma[1]. | [IC 50]
JAK2; Stat-3; Mcl-1 | [References]
[1] Sagawa M, et al. TM-233 Exerts Anti-Myeloma Activity and Overcomes Bortezomib-Resistance In Human Multiple Myeloma Cells By Targeting NF-κB and JAK/STAT Dual-Signaling Pathways[J]. Blood, 2013, 122(21): 4427. |
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