| Identification | Back Directory | [Name]
Thiazolo[3,2-a]benzimidazole-2-carboxylic acid, 3-methyl-, 2-[(phenylamino)thioxomethyl]hydrazide | [CAS]
1103920-19-9 | [Synonyms]
Anti-inflammatory agent 8
Thiazolo[3,2-a]benzimidazole-2-carboxylic acid, 3-methyl-, 2-[(phenylamino)thioxomethyl]hydrazide | [Molecular Formula]
C18H15N5OS2 | [MOL File]
1103920-19-9.mol | [Molecular Weight]
381.47 |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 8 (compound 13) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 8 expresses activity on COX-2 enzyme more than COX-1 with an IC50 of 0.09 nM. Anti-inflammatory agent 8 is orally active[1]. | [References]
[1] Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644. DOI:10.1016/j.bioorg.2022.105644 |
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