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1104027-46-4

1104027-46-4 Structure

1104027-46-4 Structure
IdentificationBack Directory
[Name]

2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
[CAS]

1104027-46-4
[Synonyms]

2-benzyl-5-chloro-3,4-dihydro-1H-2,6-naphthyridine
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine
5-Chloro-1,2,3,4-tetrahydro-2-(benzyl)-2,6-naphthyridine
5-Chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-2,6-naphthyridine
2,6-Naphthyridine, 5-chloro-1,2,3,4-tetrahydro-2-(phenylmethyl)-
2-benzyl-5-chloro-1,2,3,4-tetrahydro-2,6-naphthyridine hydrochloride
2,6-Naphthyridine-2(1H)-carboxylic acid, 5-chloro-3,4-dihydro-, 1,1-dimethylethyl ester
[Molecular Formula]

C15H15ClN2
[MDL Number]

MFCD11846202
[MOL File]

1104027-46-4.mol
[Molecular Weight]

258.746
Chemical PropertiesBack Directory
[Boiling point ]

377.5±42.0 °C(Predicted)
[density ]

1.227
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
[pka]

5.38±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

5-Chloro-1,?2,?3,?4-tetrahydro-?2-?(phenylmethyl)?-2,?6-naphthyridine is an intermediate used to prepare substituted naphthyridines as FAAH modulators useful in prevention and treatment of FAAH-mediated diseases.
[Synthesis]

A round bottom flask was charged with 6-benzyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1-ol (7 g, 29 mmol) and phosphorochloridic acid {LeonidChemicals, India; add 80 mL) and heated to reflux for 16 hours to monitor the progress of the reaction by TLC. Upon c
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