| Identification | Back Directory | [Name]
SNT-207858 free base | [CAS]
1104662-66-9 | [Synonyms]
SNT-207858 free base
1-Pyrrolidinecarboxamide, N-[(1R)-1-[(2,4-dichlorophenyl)methyl]-2-oxo-2-[4-[3-[(2R)-2-(1-pyrrolidinyl)butoxy]-2-pyridinyl]-1-piperidinyl]ethyl]- | [Molecular Formula]
C32H43Cl2N5O3 | [MOL File]
1104662-66-9.mol | [Molecular Weight]
616.62 |
| Chemical Properties | Back Directory | [Boiling point ]
813.0±65.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (202.72 mM) | [form ]
Solid | [pka]
12.71±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. | [in vivo]
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1]. | Animal Model: | Mice with C26 adenocarcinoma-induced cachexia model[1] | | Dosage: | 30 mg/kg | | Administration: | Oral administration; once daily; 15 days | | Result: | Significantly reduced the tumor induced weight loss. |
| [IC 50]
MC4R | [storage]
Store at -20°C | [References]
[1] Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774. DOI:10.1371/journal.pone.0004774 |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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