| Identification | Back Directory | [Name]
N 556 | [CAS]
110816-78-9 | [Synonyms]
N 556
KY-556
5,5'-[[2-(Lysyloxy)propane-1,3-diyl]bisoxy]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid ethyl]·2hydrochloride | [Molecular Formula]
C33H36N2O12.2ClH | [MDL Number]
MFCD06809908 | [MOL File]
110816-78-9.mol | [Molecular Weight]
725.571 |
| Hazard Information | Back Directory | [Uses]
KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases. | [in vivo]
The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1]. | [storage]
Store at -20°C | [References]
[1] Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PMID:2096808 |
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