| Identification | Back Directory | [Name]
1H-Pyrido(2,1-b)quinazoline-8-carboxamide, N-(1-methyl-4-(3-pyridinyl) butyl)-1-oxo- | [CAS]
110996-51-5 | [Synonyms]
Ro 23-3423
1H-Pyrido(2,1-b)quinazoline-8-carboxamide, N-(1-methyl-4-(3-pyridinyl) butyl)-1-oxo- | [Molecular Formula]
C23H22N4O2 | [MOL File]
110996-51-5.mol | [Molecular Weight]
386.45 |
| Hazard Information | Back Directory | [Description]
Ro 23-3423 is a specific thromboxane synthetase inhibitor. | [Uses]
Ro 23-3423 is a thromboxane synthase inhibitor with an IC50 value of 0.33 μM for human platelet microsomal thromboxane synthase. Ro 23-3423 increases plasma levels of PGF and PGE2 in a dose-dependent manner, accompanied by a decrease in mean systemic arterial pressure and systemic vascular resistance. Ro 23-3423 can be used in the study of general anesthesia[1]. | [References]
[1] Morel D R, et al. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep[J]. Prostaglandins, 1987, 33(6): 879-902. DOI:10.1016/0090-6980(87)90116-x |
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