| Identification | Back Directory | [Name]
1,2-Benzenediol, 4-[2-(3-methyl-2-thienyl)-4-thiazolyl]- | [CAS]
1110905-26-4 | [Synonyms]
1,2-Benzenediol, 4-[2-(3-methyl-2-thienyl)-4-thiazolyl]- | [Molecular Formula]
C14H11NO2S2 | [MOL File]
1110905-26-4.mol | [Molecular Weight]
289.37 |
| Chemical Properties | Back Directory | [Boiling point ]
530.0±60.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.60±0.20(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
MTBT is an inhibitor of the proliferation of cancer cells. It induces cell cycle arrest and activates p38 MAPK. | [Uses]
MTBT is an anticancer agent and p38 activator with antiproliferative and apoptosis-inducing (apoptosis) activities. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. SB203580 (HY-10256), a specific inhibitor of p38 MAPK, abolished MTBT-induced cell cycle arrest[1]. | [References]
[1] A small molecule, MTBT, prevents cancer cell growth by activating p38 MAPK |
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