| Identification | Back Directory | [Name]
8-deazahomofolic acid | [CAS]
111113-73-6 | [Synonyms]
8-deazahomofolic acid
8Deazahomofolic acid,8 Deazahomofolic acid
L-Glutamic acid, N-[4-[[2-(2-amino-1,4-dihydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)ethyl]amino]benzoyl]- (9CI) | [Molecular Formula]
C21H22N6O6 | [MOL File]
111113-73-6.mol | [Molecular Weight]
454.44 |
| Hazard Information | Back Directory | [Uses]
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors[1]. | [References]
[1] DeGraw JI, et al. Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. J Med Chem. 1988 Jan;31(1):150-3. DOI:10.1021/jm00396a022 |
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