| Chemical Properties | Back Directory | [density ]
1.272±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
11.917±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines[1]. | [References]
[1] Abdel-Rahman SA, et al. Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. J Med Chem. 2023 Aug 24;66(16):11464-11475. DOI:10.1021/acs.jmedchem.3c00960 |
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