| Identification | Back Directory | [Name]
Amitivir | [CAS]
111393-84-1 | [Synonyms]
Amitivir
LY-217896
Cyanamide, N-1,3,4-thiadiazol-2-yl-
Inhibitor,antiviral,thomyxovirus,inhibit,paramyxovirus CD-1,mice,Influenza Virus,Amitivir | [Molecular Formula]
C3H2N4S | [MDL Number]
MFCD00866935 | [MOL File]
111393-84-1.mol | [Molecular Weight]
126.14 |
| Hazard Information | Back Directory | [Uses]
Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses[1][2]. | [Definition]
ChEBI: Amitivir is a secondary amine. | [in vivo]
Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus[2]. | [References]
[1] Hayden FG, et al. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994;38(5):1178-1181. DOI:10.1128/AAC.38.5.1178
[2] Colacino JM, et al. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990;34(11):2156-2163. DOI:10.1128/AAC.34.11.2156 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|