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1114507-62-8

1114507-62-8 Structure

1114507-62-8 Structure
IdentificationBack Directory
[Name]

4(3H)-PyriMidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-Methoxyphenyl)cyclopropyl]Methyl]thio]-5-Methyl-
[CAS]

1114507-62-8
[Synonyms]

4(3H)-PyriMidinone, 6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[[(1R,2R)-2-(4-Methoxyphenyl)cyclopropyl]Methyl]thio]-5-Methyl-
6-[(1R)-1-(2,6-difluorophenyl)ethyl]-2-[[(1R,2R)-2-(4-methoxyphenyl)cyclopropyl]methylsulfanyl]-5-methyl-1H-pyrimidin-4-one
[Molecular Formula]

C24H24F2N2O2S
[MOL File]

1114507-62-8.mol
[Molecular Weight]

442.521
Hazard InformationBack Directory
[Uses]

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC50 of 0.07 nM in NL4-3 wt MT-4 cells[1].
[References]

[1] Marco Radi, et al. Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. J Med Chem. 2009 Feb 12;52(3):840-51. DOI:10.1021/jm801330n
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