| Identification | Back Directory | [Name]
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE | [CAS]
111686-79-4 | [Synonyms]
fpl12924aa
pr934-423a
RemacemideHCl
REMACEMIDE HYDROCHLORIDE
2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid | [Molecular Formula]
C17H21ClN2O | [MDL Number]
MFCD00882179 | [MOL File]
111686-79-4.mol | [Molecular Weight]
304.81 |
| Chemical Properties | Back Directory | [Melting point ]
253-254° | [storage temp. ]
room temp | [solubility ]
H2O: >10mg/mL | [form ]
powder | [color ]
white to beige | [Water Solubility ]
Soluble to 100 mM in water | [InChI]
1S/C17H20N2O.ClH/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14;/h2-11H,12-13,18H2,1H3,(H,19,20);1H | [InChIKey]
HYQMIUSWZXGTCC-UHFFFAOYSA-N | [SMILES]
Cl.CC(Cc1ccccc1)(NC(=O)CN)c2ccccc2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-41-50/53 | [Safety Statements ]
26-39-45-60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [RTECS ]
AB4349500 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Eye Dam. 1 | [Toxicity]
LD50 (calculated as base) in rats (mg/kg): ~50 i.v., ~900 orally (Muir, Palmer) |
| Hazard Information | Back Directory | [Uses]
Anticonvulsant (neuroprotective). | [Biological Activity]
Non-competitive NMDA receptor antagonist; blocks ion channel and allosteric modulatory site (IC 50 = 8-68 mM). Anticonvulsant in vivo and metabolizes to a more potent desglycine analog. Weakly blocks voltage-dependent Na + channels (IC 50 = 161 mM). | [Biochem/physiol Actions]
Remacemide HCl is a low affinity NMDA antagonist with anticonvulsant properties. Remacemide also been shown to block voltage-dependent sodium channels. | [in vivo]
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3]. | Animal Model: | Female Sprague–Dawley rats ( 190-210 g )[3] | | Dosage: | 100 mg/kg and 150 mg/kg | | Administration: | Orogastric gavage; once a day; 7 days | | Result: | Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
|
| [storage]
Desiccate at RT |
|
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SynAsst Chemical.
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