| Identification | Back Directory | [Name]
7-Deaza-ddG | [CAS]
111869-49-9 | [Synonyms]
7-Deaza-ddG
2',3'-Dideoxy-7-Deazaguanosine
2-Amino-7-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]- (9CI) | [Molecular Formula]
C11H14N4O3 | [MDL Number]
MFCD07778654 | [MOL File]
111869-49-9.mol | [Molecular Weight]
250.25 |
| Chemical Properties | Back Directory | [Melting point ]
228 °C (decomp) | [density ]
1.75±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.29±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C11H14N4O3/c12-11-13-9-7(10(17)14-11)3-4-15(9)8-2-1-6(5-16)18-8/h3-4,6,8,16H,1-2,5H2,(H3,12,13,14,17)/t6-,8+/m0/s1 | [InChIKey]
IRKZBFORRGBSAO-POYBYMJQSA-N | [SMILES]
C1(N)=NC(=O)C2C=CN([C@H]3CC[C@@H](CO)O3)C=2N1 |
| Hazard Information | Back Directory | [Uses]
7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1]. | [IC 50]
HIV-1 | [References]
[1] Nicholas A Boyle, et al. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48(7):2695-700. DOI:10.1021/jm040101y |
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