| Identification | Back Directory | [Name]
Adenanthin | [CAS]
111917-59-0 | [Synonyms]
Adenanthin
Actinodephnine Acuminatin Acuminatoside Adenanthin
Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-
Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI) | [Molecular Formula]
C26H34O9 | [MDL Number]
MFCD20260622 | [MOL File]
111917-59-0.mol | [Molecular Weight]
490.55 |
| Hazard Information | Back Directory | [Enzyme inhibitor]
This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid. |
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