| Identification | Back Directory | [Name]
2-(3,4-difluorophenyl)oxirane | [CAS]
111991-13-0 | [Synonyms]
Ticagrelor Impurity 101
(3,4-Difluorophenyl)oxirane
2-(3,4-difluorophenyl)oxirane
Oxirane, (3,4-difluorophenyl)-
Oxirane, 2-(3,4-difluorophenyl)- | [Molecular Formula]
C8H6F2O | [MDL Number]
MFCD09728790 | [MOL File]
111991-13-0.mol | [Molecular Weight]
156.13 |
| Chemical Properties | Back Directory | [Boiling point ]
186.8±40.0 °C(Predicted) | [density ]
1.335±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C |
| Hazard Information | Back Directory | [Synthesis]
Under nitrogen protection, 14 g (100 mmol) of 3,4-difluorostyrene was dissolved in tetrahydrofuran. A 30% hydrogen peroxide solution (300 mmol) was slowly added dropwise at 20 °C, keeping the reaction temperature constant with continuous stirring for 4 hours. After completion of the reaction, water was added to the reaction mixture for stratification. The organic layer was separated and washed with appropriate amount of water. Subsequently, the organic layer was concentrated under reduced pressure and finally purified by column chromatography to afford 7.3 g of 2-(3,4-difluorophenyl)oxirane in 46.7% yield and 19.43% enantiomeric excess (ee) value. | [References]
[1] Patent: CN106631887, 2017, A. Location in patent: Paragraph 0034-0035 |
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Energy Chemical
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ChemeGen
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https://www.chemegen.com |
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