| Identification | Back Directory | [Name]
Tebufelone | [CAS]
112018-00-5 | [Synonyms]
NE-11740
Tebufelone
1-(3,5-Ditert-butyl-4-hydroxyphenyl)-5-hexyn-1-one
5-Hexyn-1-one, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]- | [Molecular Formula]
C20H28O2 | [MDL Number]
MFCD00864365 | [MOL File]
112018-00-5.mol | [Molecular Weight]
300.44 |
| Hazard Information | Back Directory | [Uses]
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2]. | [IC 50]
COX-2; 5-LO | [References]
[1] S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. DOI:10.1007/BF02001910
[2] Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206. DOI:10.1002/cmdc.202300206 |
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Leancare Ltd.
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