| Identification | Back Directory | [Name]
Ro 314724 | [CAS]
112105-54-1 | [Synonyms]
Ro 314724
L-Alanine, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-L-leucyl-, ethyl ester | [Molecular Formula]
C19H35N3O6 | [MDL Number]
MFCD00907191 | [MOL File]
112105-54-1.mol | [Molecular Weight]
401.5 |
| Hazard Information | Back Directory | [Description]
RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants. |
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