| Hazard Information | Back Directory | [Description]
CM572 is a selective antagonist of the putative sigma-2. | [Uses]
CM572 is a selective irreversible partial sigma-2 receptor agonist. CM572 has antitumor activity. CM572 induces dose-dependent cell death, with an EC50 of 7.6 μM in SK-N-SH neuroblastoma cells. CM572 can be used for the research of kinds of diseases such as neuroblastoma, breast cancer[1]. | [References]
[1] Nicholson H, et al. Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. DOI:10.1124/jpet.115.224105 |
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