| Identification | Back Directory | [Name]
8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine | [CAS]
1124382-72-4 | [Synonyms]
106347
EOS-61162
8-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine
2-AMino-8-broMo[1,2,4]triazolo[1,5-a]pyridine
8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
[1,2,4]Triazolo[1,5-a]pyridin-2-amine, 8-bromo-
8-bromo - [1,2,4] thiazolo [1,5-a] pyridine-2-amine | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C6H5BrN4 | [MDL Number]
MFCD16658939 | [MOL File]
1124382-72-4.mol | [Molecular Weight]
213.035 |
| Chemical Properties | Back Directory | [density ]
2.09 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
solid | [pka]
3.83±0.30(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H5BrN4/c7-4-2-1-3-11-5(4)9-6(8)10-11/h1-3H,(H2,8,10) | [InChIKey]
SUFKKFLJJMKVJJ-UHFFFAOYSA-N | [SMILES]
C12=NC(N)=NN1C=CC=C2Br |
| Questions And Answer | Back Directory | [Uses]
8-Bromo-[1,2,4]thiazo[1,5-a]pyridine-2-amine is a pyridine derivative that can be used as a pharmaceutical synthesis intermediate for pharmaceutical synthesis and experimental research. |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 2-amino-8-bromo[1,2,4]triazolo[1,5-a]pyridine from compound (CAS:1124383-00-1) is as follows:
1. Dissolution step: Methanol (MeOH, 300 mL), hydroxylamine hydrochloride (62.83 g, 904 mmol) and diisopropylethylamine (DIPEA, 694 mL, 543 mmol) were added to a solution of Intermediate 50 (55 g, 181 mmol) in ethanol (EtOH, 300 mL).
2. Reaction step: the reaction mixture was stirred at room temperature (r.t.) for 6 hours.
3. Post-treatment step: the reaction mixture was concentrated in vacuum and the residue was suspended in diisopropyl ether (DIPE).
4. Separation step: the precipitate was collected by filtration. 5.
5. Yield: 51 37 g of intermediate were obtained in 96% yield. | [References]
[1] Patent: WO2013/10904, 2013, A1. Location in patent: Page/Page column 76
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 17, p. 4794 - 4800
[3] Patent: KR2015/77599, 2015, A. Location in patent: Paragraph 0096; 0099-0101
[4] Patent: KR101601354, 2016, B1. Location in patent: Paragraph 0110 - 0112
[5] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 66 |
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