| Hazard Information | Back Directory | [Description]
FR 78844 is a bone resorption antagonist. | [Uses]
FR 78844 is a potent and orally active bone resorption inhibitor. FR 78844 has the potential for the research of diabetes associated osteopenia[1]. | [in vivo]
FR 78844 (1, 10, 100 mg/kg; p.o.; 5 days a week for 4 weeks) attenuates the decrease of metaphyseal bone mineral density in rats[1]. | Animal Model: | Nine weeks old female Wistar rats (streptozotocin(STZ)-diabetic rats) [1] | | Dosage: | 1, 10, 100 mg/kg | | Administration: | P.o.; 5 days a week for 4 weeks | | Result: | Significantly attenuated the decrease of metaphyseal bone mineral density. |
| [References]
[1] Takeshita N, et al. Possible involvement of vitamin D3-deficiency and relatively enhanced bone resorption in the development of bone loss in streptozotocin-induced diabetic rats. Life Sci. 1994;55(4):291-9. DOI:10.1016/0024-3205(94)00731-4 |
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