| Identification | Back Directory | [Name]
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine | [CAS]
112914-13-3 | [Synonyms]
2-Aminoethy-4-(4-Fluorobenzyl)-morpholine
2-Aminomethy-4-(4-fluorobenzyl)morpholine
(4-(4-Fluorobenzyl)Morpholin-2-yl)MethanaMine
2-Aminomethy-4-(4-fluorobenzyl)morpholine, >=98%
4-[(4-Fluorophenyl)methyl]-2-morpholinemethamine
4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine
2-Morpholinemethanamine,4-[(4-fluorophenyl)methyl]-
[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methanamine
{4-[(4-fluorophenyl)Methyl]Morpholin-2-yl}MethanaMine
2-(AminoMethyl)-4-(4-FluoroBenzyl)Morpholine,Mosapride
C-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YL]-METHYLAMINE DIHYDROCHLORIDE
2-(Aminomethyl)-4-(4-fluorobenzyl)morpholine, 1-{[2-(Aminomethyl)morpholin-4-yl]methyl}-4-fluorobenzene | [Molecular Formula]
C12H17FN2O | [MDL Number]
MFCD09029017 | [MOL File]
112914-13-3.mol | [Molecular Weight]
224.27 |
| Chemical Properties | Back Directory | [Boiling point ]
317.4±27.0 °C(Predicted) | [density ]
1.145±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
9.37±0.29(Predicted) | [color ]
Pale Yellow to Light Yellow | [InChI]
InChI=1S/C12H17FN2O/c13-11-3-1-10(2-4-11)8-15-5-6-16-12(7-14)9-15/h1-4,12H,5-9,14H2 | [InChIKey]
JHSPPBBJOLKJDH-UHFFFAOYSA-N | [SMILES]
N1(CC2=CC=C(F)C=C2)CCOC(CN)C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Pale Yellow Oil | [Uses]
Mosapride intermediate. | [Synthesis]
General procedure for the synthesis of 2-aminomethyl-4-(4-fluorobenzyl)-morpholine from N-(2,3-epoxypropyl)phthalimide and 2-(4-fluorobenzylamino)ethanol: 2-(4-fluorobenzylamino)ethanol (28.7 g, 0.17 mol) and N-(2,3-epoxypropyl)phthalimide (35.0 g, 0.13 mol) were added to the reaction kettle. The reaction was heated to 70-80°C and held for 3 hours. Subsequently, sulfuric acid was slowly added dropwise at 70-90°C and the reaction was continued at 125-145°C for 2.5 hours. Upon completion of the reaction, the mixture was transferred to cold water, cooled to 0°C, crystallized and filtered. The filtrate was neutralized with sodium hydroxide, extracted with chloroform, dried the organic phase and concentrated to dryness to give 4-(4-fluorobenzyl)-2-aminomethylmorpholine as a light yellow oil (yield: 75.1%, purity: 80.2%). | [References]
[1] Patent: CN108341788, 2018, A. Location in patent: Paragraph 0074; 0075; 0076
[2] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 8, p. 1484 - 1492
[3] Patent: CN108129414, 2018, A. Location in patent: Paragraph 0050; 0053; 0054 |
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