| Identification | Back Directory | [Name]
1-Propanol, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- (9CI) | [CAS]
112935-57-6 | [Synonyms]
OH-Pr-PEG2-Pr-OH
Propanol-PEG3-CH2OH
HO-PPG1-PEG2-PPG1-OH
1-Propanol, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- (9CI) | [Molecular Formula]
C10H22O5 | [MDL Number]
MFCD34471267 | [MOL File]
112935-57-6.mol | [Molecular Weight]
222.28 |
| Hazard Information | Back Directory | [Uses]
Propanol-PEG3-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Propanol-PEG3-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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